{"id":3165,"date":"2020-09-30T10:14:01","date_gmt":"2020-09-30T02:14:01","guid":{"rendered":"https:\/\/geneusmtc.com\/?p=3165"},"modified":"2020-09-30T10:16:26","modified_gmt":"2020-09-30T02:16:26","slug":"%e4%b8%ad%e7%a7%8b%e9%a3%9f%e6%9f%9a%ef%bc%8c%e3%80%8c%e8%97%a5%e3%80%8d%e7%95%b6%e5%bf%83%ef%bc%81","status":"publish","type":"post","link":"https:\/\/geneusmtc.com\/%e4%b8%ad%e7%a7%8b%e9%a3%9f%e6%9f%9a%ef%bc%8c%e3%80%8c%e8%97%a5%e3%80%8d%e7%95%b6%e5%bf%83%ef%bc%81\/","title":{"rendered":"\u4e2d\u79cb\u98df\u67da\uff0c\u300c\u85e5\u300d\u7576\u5fc3\uff01"},"content":{"rendered":"

\u4e2d\u79cb\u98df\u67da\uff0c\u300c\u85e5\u300d\u7576\u5fc3\uff01<\/h2>\n<\/div>

\u518d\u904e\u5e7e\u5929\u5c31\u662f\u4e2d\u79cb\u7bc0\u4e86\uff0c\u76f8\u4fe1\u5927\u5bb6\u9664\u4e86\u6708\u9905\u5916\uff0c\u9999\u5674\u5674\u7684\u70e4\u8089\u53ca\u9ec3\u6f84\u6f84\u7684\u67da\u5b50\u4e00\u5b9a\u4e5f\u662f\u5bb6\u5ead\u5718\u805a\u7684\u9996\u90781<\/sup>\u3002\u7136\u800c\uff0c\u5728\u9019\u500b\u6b61\u6a02\u7684\u6c23\u6c1b\u7576\u4e2d\uff0c\u9084\u662f\u6709\u8a31\u591a\u6f5b\u4f0f\u7684\u5371\u6a5f\uff0c\u5c24\u5176\u662f\u670d\u7528\u964d\u8840\u8102\u85e5\u7269- Statin\u7684\u75c5\u60a3\uff0c\u5230\u5e95\u53ef\u4e0d\u53ef\u4ee5\u5403\u67da\u5b50\u5462?\u3002<\/p>\n

\u5728\u63a2\u8a0e\u9019\u500b\u554f\u984c\u524d\uff0c\u5fc5\u9808\u5148\u4e86\u89e3\u4ec0\u9ebc\u662fStatin\u548c\u5176\u9ad4\u5167\u7684\u4ee3\u8b1d\u9014\u5f91\u3002\u4f9d\u64da\u82f1\u570b\u570b\u6c11\u5065\u4fdd\u5c40\u5c0dStatin\u7684\u5b9a\u7fa9\uff0cStatin\u5c31\u662f\u4e00\u7cfb\u5217\u53ef\u4ee5\u964d\u4f4e\u8840\u6db2\u4e2d\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u7684\u85e5\u72692<\/sup>\u3002\u85e5\u5e2b\u516c\u6703\u5168\u806f\u6703\u767c\u884c\u7684\u85e5\u5e2b\u9031\u520a\u96fb\u5b50\u5831\u5c0dStatin\u7684\u95e1\u8ff0\u662f\u9019\u6a23\u7684\uff1a\u6240\u8b02\u7684Statin\u85e5\u7269\u5c31\u662fHMG-CoA\u9084\u539f\u6291\u5236\u5291\uff0c\u662f\u4e00\u7a2e\u5e38\u898b\u4e4b\u964d\u8840\u8102\u85e5\u7269\u3002\u9019\u985e\u85e5\u7269\u5305\u542blovastatin\u3001simvastatin\u3001atorvastatin\u3001pravastatin\u53carosuvastatin\u7b49\uff0c\u7d93\u7531\u6291\u5236HMG-CoA\u9084\u539f\u6e1b\u5c11\u81bd\u56fa\u9187\u5408\u6210\uff0c\u8a98\u767c\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u63a5\u53d7\u5668\u7684\u589e\u52a0\u4e26\u4f7f\u81bd\u56fa\u9187\u6e05\u9664\u63d0\u9ad8\uff0c\u6700\u986f\u8457\u7684\u7642\u6548\u5c31\u662f\u4f7f\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u4e0b\u964d3<\/sup>\u3002<\/p>\n

\u5176\u4e2dsimvastatin \u53caatorvastatin\u662f\u7531\u809d\u81df\u7684CYP3A4<\/em>\u9175\u7d20\u6240\u4ee3\u8b1d4<\/sup>\u3002\u4e0d\u904e\uff0c\u5728\u591a\u7a2e\u852c\u679c\uff0c\u50cf\u662f\u67da\u5b50\u3001\u77f3\u69b4\u3001\u82b9\u83dc\u7b49\u4e2d\u537b\u542b\u6709CYP3A4<\/em>\u9175\u7d20\u7684\u6291\u5236\u5291\u2013\u5583\u9999\u8c46\u7d20 (furanocoumarins) 5<\/sup>\u3002\u53ef\u60f3\u800c\u77e5\uff0c\u7576\u670d\u7528\u4e86\u9019\u985e\u852c\u679c\uff0cCYP3A4<\/em>\u9175\u7d20\u7684\u85e5\u7269\u4ee3\u8b1d\u529f\u80fd\u6703\u88ab\u6291\u5236\uff0c\u6240\u4ee5\u6b63\u5728\u670d\u7528simvastatin \u6216atorvastatin\u7684\u75c5\u60a3\uff0c\u5176\u8840\u6db2\u4e2d\u7684\u85e5\u7269\u6fc3\u5ea6\u5c31\u6703\u56e0\u7121\u6cd5\u4ee3\u8b1d\u800c\u904e\u9ad8\uff0c\u56b4\u91cd\u8005\u6703\u7522\u751f\u5614\u5410\u3001\u808c\u8089\u75e0\u75db\u548c\u808c\u7121\u529b\u7b49\u75c7\u72c0\u3002\u6b63\u56e0\u70ba\u5982\u6b64\uff0c\u53f0\u7063\u885b\u798f\u90e8\u4ea6\u66fe\u7279\u5225\u63d0\u9192\u4e2d\u79cb\u4f73\u7bc0\u6b63\u5728\u670d\u7528\u964d\u8840\u8102\u85e5\u7269\u7684\u75c5\u60a3\uff0c\u67da\u5b50\u6dfa\u5617\u5373\u53ef\uff0c\u5207\u8a18\u52ff\u5927\u91cf\u98df\u75286<\/sup>\u3002<\/p>\n

\u53e6\u5916\uff0c\u5403\u67da\u5b50\u7684\u78ba\u6703\u53bb\u5f71\u97ff\u809d\u81dfCYP3A4<\/em>\u9175\u7d20\u7684\u85e5\u7269\u4ee3\u8b1d\u529f\u80fd\uff0c\u4f46\u5f71\u97ff\u75c5\u60a3\u4ee3\u8b1dStatin\u85e5\u7269\u80fd\u529b\u7684\u539f\u56e0\u9084\u5305\u62ec\u662f\u5426\u5e36\u6709CYP3A4<\/em>\u57fa\u56e0\u7684\u8b8a\u7570\u30027<\/sup>\u4e5f\u5c31\u662f\u8aaa\uff0c\u5e36\u6709CYP3A4<\/em>\u57fa\u56e0\u8b8a\u7570\u7684\u4eba\uff0c\u5c0d\u65bc\u6b64\u985eStatin\u85e5\u7269\u672c\u8eab\u53ef\u80fd\u5c31\u5c6c\u65bc\u7de9\u6162\u4ee3\u8b1d\u578b\uff0c\u56e0\u6b64\u7576\u6709\u6b64\u9ad4\u8cea\u7684\u75c5\u60a3\uff0c\u82e5\u53c8\u98df\u7528\u5927\u91cf\u67da\u5b50\u6216\u8461\u8404\u67da\u6c41\uff0c\u6703\u8b93\u5176\u670d\u7528\u7684\u964d\u8840\u8102\u85e5\u7269\u66f4\u5bb9\u6613\u7d2f\u7a4d\u65bc\u9ad4\u5167\uff0c\u9020\u6210\u56b4\u91cd\u526f\u4f5c\u7528\u3002<\/p>\n

\u96d6\u7136\u76ee\u524d\u53f0\u7063\u5728\u958b\u7acb\u6b64\u985e\u964d\u8840\u8102\u85e5\u7269\u8655\u65b9\u4ecd\u672a\u5c07\u57fa\u56e0\u8b8a\u7570\u7684\u56e0\u7d20\u52a0\u5165\u8003\u91cf8<\/sup>\uff0c\u4f46\u82e5\u60f3\u77e5\u9053\u81ea\u5df1\u662f\u5426\u70ba\u6b64\u985e\u9ad4\u8cea\u7684\u4eba\uff0c\u53ef\u4ee5\u9078\u64c7\u672c\u516c\u53f8\u5065\u5eb7\u5148\u77e5\u7cbe\u83ef\u7248\u7528\u57fa\u56e0\u6aa2\u6e2c\u7684\u65b9\u5f0f\u4f86\u6aa2\u8996\u81ea\u5df1\u7684\u85e5\u7269\u4ee3\u8b1d\u80fd\u529b\u3002\u82e5\u6709\u76f8\u95dc\u7591\u554f\uff0c\u6b61\u8fce\u8207\u672c\u516c\u53f8\u806f\u7d61\u3002<\/p>\n

#Statin # CYP3A4<\/em>\u57fa\u56e0 #\u57fa\u56e0\u6aa2\u6e2c #\u5065\u5eb7\u5148\u77e5\u7cbe\u83ef\u7248<\/p>\n

\"\"<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/p>\n

    \n
  1. https:\/\/www.setn.com\/News.aspx?NewsID=818557<\/a><\/li>\n
  2. https:\/\/www.nhs.uk\/conditions\/statins\/<\/a><\/li>\n
  3. https:\/\/www.taiwan-pharma.org.tw\/weekly\/1525\/0602.htm<\/a><\/li>\n
  4. https:\/\/www.medsafe.govt.nz\/profs\/PUArticles\/March2014StatinsAndCYPInteractions.htm#:~:text=CYP3A4%20inhibitors%20may%20increase%20the,for%20the%20duration%20of%20therapy<\/a>.<\/li>\n
  5. https:\/\/www.amjmed.com\/article\/S0002-9343(15)00774-3\/fulltext<\/a><\/li>\n
  6. https:\/\/www.mohw.gov.tw\/cp-2648-20155-1.html<\/a><\/li>\n
  7. https:\/\/www.intechopen.com\/online-first\/pharmacokinetic-aspects-of-statins<\/a><\/li>\n<\/ol>\n

    http:\/\/www.airitilibrary.com\/Publication\/alDetailedMesh1?DocID=U0026-0408201501335800<\/a><\/p>\n<\/div>

    <\/div><\/div><\/div><\/div><\/div>

    \u806f\u7d61\u6676\u6e96<\/span><\/h2>\n<\/div>

    \u5c0d\u65bc\u6211\u5011\u7684\u7522\u54c1\u8cc7\u8a0a\u9084\u6709\u7591\u60d1\u55ce\uff1f<\/span><\/p>\n

    \u6b61\u8fce\u8a62\u554f\u6211\u5011\u5c08\u696d\u7684\u91ab\u5b78\u5ba2\u670d\u5c08\u54e1\uff0c\u6211\u5011\u6703\u76e1\u5feb\u8207\u60a8\u806f\u7d61\u3002<\/span><\/p>\n<\/div>

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